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KMID : 0604520180440040375
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 4 p.375 ~ p.379
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Skin Protective Effect of Methylated Marliolide through Induction of NRF2/ARE
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Lee June
Kim Ki-Seong
Lee Hyun-Gy
Park Chang-Ho
Ku Min-Su
Keum Young-Sam
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Abstract
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In the present study, we have investigated whether methylated marliolide could induce NRF2 thereby exerting anti-oxidant effects. MTT assay showed that methylated marliolide did not exhibit cytotoxicity on HaCaT cells. Methylated marliolide induced a higher ARE-dependent luciferase activation in HaCaT ARE-GFP-luciferase cells, compared with resveratrol. In addition, exposure of methylated marliolide to HaCaT cells significantly induced NRF2 and transcriptionally activated HO-1 and NQO1, both of which are target genes of NRF2. Finally, methylated marliolide protected HaCaT cells against TPA-induced oxidative damages on nucleotides and lipids. Together, results shows that methylated marliolide could suppress oxidative damages through induction of NRF2 which implies that methylated marliolide might serve as a good candidate for novel cosmetic ingredient with anti-oxidant effects.
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KEYWORD
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Oxidative stress, NRF2 (NF-E2-related factor 2), ARE (antioxidant response element), methylated marliolide
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